Interactive Demo
The RB/E2F Bistable Switch
The RB/E2F Bistable Switch is a free, interactive learning demo from the Introductory Biology course on Lykke. It helps you build intuition for Cyclins and Cdks, Checkpoints (RB/E2F), Proto-oncogenes, Tumor Suppressors. Play with it directly in your browser — it features 2 sliders, 2 buttons and a live visual canvas. This demo lives in the “Cell Cycle Regulation and Cancer Biology” section of the course.
How to use this demo
- Drag the “Mitogen Level (Growth Factors)”, “Oncogenic Mutations”, “E2F Activity (S-Phase Entry)” sliders to change the inputs and watch the result update live.
- Use the “Loss of RB (Tumor Suppressor)”, “Cyclin D Overexpression” buttons to trigger actions or reset the demo.
- Experiment freely — there's nothing to break, and every change is reversible.
What you'll explore
- Cyclins and Cdks
- Checkpoints (RB/E2F)
- Proto-oncogenes
- Tumor Suppressors
- Apoptosis
Frequently asked questions
What does the The RB/E2F Bistable Switch demo do?
The control of cell division and the genetic basis of cancer. The RB/E2F Bistable Switch turns that idea into something you can manipulate directly and watch respond.
What Introductory Biology concept does The RB/E2F Bistable Switch teach?
The control of cell division and the genetic basis of cancer. It focuses on Cyclins and Cdks, Checkpoints (RB/E2F), Proto-oncogenes, Tumor Suppressors, Apoptosis from the “Cell Cycle Regulation and Cancer Biology” section.
What can I control in The RB/E2F Bistable Switch?
The “Mitogen Level (Growth Factors)”, “Oncogenic Mutations”, “E2F Activity (S-Phase Entry)” sliders change the key inputs; the “Loss of RB (Tumor Suppressor)”, “Cyclin D Overexpression” buttons run actions or reset the demo. Every change updates the visualization in real time, so you can see exactly how each variable affects the outcome.
How does The RB/E2F Bistable Switch fit into the Introductory Biology course?
7.016 Introductory Biology provides a comprehensive exploration of the molecular and cellular foundations of life, integrating biochemistry, genetics, and molecular biology. The course emphasizes the structure and regul… This demo is the interactive piece for the “Cell Cycle Regulation and Cancer Biology” section. Open the full Introductory Biology course wiki at https://www.getlykke.com/explore/public/introductory-biology-b36950be-aafa-4e22-9bdc-b291f812acc8 for notes, flashcards, quizzes and the other demos.
What will I understand better after using The RB/E2F Bistable Switch?
You'll build intuition for Cyclins and Cdks, Checkpoints (RB/E2F), Proto-oncogenes, Tumor Suppressors, Apoptosis — and, crucially, see how they behave when you change the inputs, which is hard to get from a textbook or lecture on Introductory Biology alone.
From the Introductory Biology course
This interactive demo is part of the Cell Cycle Regulation and Cancer Biology section. Explore the full Introductory Biology course wiki on Lykke — with notes, flashcards, quizzes and more interactive demos.
Open the Introductory Biology course →